Delayed treatment with vitamin C and N-acetyl-L cysteine protects Schwann cells without compromising the anti-myeloma activity of bortezomib

Nakano A, Abe M, Oda A, Amou H, Hiasa M, Nakamura S, Miki H, Harada T, Fujii
S, Kagawa K, Takeuchi K, Watanabe T, Ozaki S, Matsumoto T. Delayed treatment
with vitamin C and N-acetyl-L: -cysteine protects Schwann cells without
compromising the anti-myeloma activity of bortezomib. Int J Hematol. 2011
Apr 28. [Epub ahead of print] PubMed PMID: 21526377

Vitamin C or N-acetyl-L: -cysteine (NAC) achieved near-complete rescue of
Schwann cells treated with bortezomib at 30 nM or less, and these agents in
combination are able to cooperatively inhibit the morphological changes and
the cytotoxicity in Schwann cells with higher doses of bortezomib. The
delayed addition of vitamin C and/or NAC after the exposure to bortezomib
alleviated the cytotoxicity in Schwann cells but not myeloma cells.

http://www.ncbi.nlm.nih.gov/pubmed/21526377