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Vitamin C increases the apoptosis via up-regulation p53 during cisplatin treatment in human colon cancer cells

By admin - Posted on 05 April 2011

An SH, Kang JH, Kim DH, Lee MS. Vitamin C increases the apoptosis via
up-regulation p53 during cisplatin treatment in human colon cancer cells.
BMB Rep. 2011 Mar;44(3):211-6. PubMed PMID: 21429301

We measured the expression of p53 level involved in the effect of VC on
CDDP-induced apoptosis of HCT116, a human colon cancer cell line. CDDP plus
VC treatment resulted in significantly increased apoptosis along with
upregulation of p53 compared to untreated cells and/or CDDP-treated cells.
These results suggest that VC enhanced CDDP sensitivity and apoptosis via
upregulation of p53.

http://www.ncbi.nlm.nih.gov/pubmed/21429301

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Access to Parenteral Thiamine

Biological Therapies supplies a range of registered injections containing parenteral thiamine.
See the TGA website: http://www.tga.gov.au/safety/alerts-medicine-ivthiamine-100728.htm
See also the SHPA website: SHPA Manufacturers Alerts (Thiamine Injection)

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Transmission of hepatitis C virus to recipients of parenteral vitamin therapy in a primary care facility.

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Vitamin C increases the apoptosis via up-regulation p53 during cisplatin treatment in human colon cancer cells

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Preclinical evaluation of the antitumor activity of bortezomib in combination with vitamin C

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Revisiting the ALA-N (alpha-lipoic acid - low-dose naltrexone) protocol for people with pancreatic cancer

Effect of thiamine administration on metabolic profile, cytokines and inflammatory markers in type 2 diabetes patients

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From Ian's Desk

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