You are hereBlogs

Blogs


Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN)

VC was maintained and survival was DOUBLE other studies using VC with gemcitabine and dramatically better than non VC studies.  Toxicity was acceptable.  Data suggest pharmacologic ascorbate administered concurrently with gemcitabine is well tolerated. Initial data from this small sampling suggest some efficacy. Further studies powered to determine efficacy should be conducted.

http://www.ncbi.nlm.nih.gov/pubmed/23381814

Co-infusing Glutathione and Vitamin C during cancer treatment: a reply

Dettman I, Meakin C, Allen R; Co-infusing Glutathione and Vitamin C during cancer treatment: A reply. ACNEM Journal, Mar 2012, Vol 31 No. 1 p 8-11

Effect of oral suplementation of vitamin C on intestinal anastomotic resistance

Petroianu A, Alberti LR. Effect of oral suplementation of vitamin C on
intestinal anastomotic resistance. Rev Col Bras Cir. 2011 Feb;38(1):54-58.
English, Portuguese. PubMed PMID: 21537744

The rats that received vitamin C had higher anastomotic bursting pressure in
the fifth, seventh and 28th postoperative days. The same happened with the
bursting pressures of intact jejunal segments.


http://www.ncbi.nlm.nih.gov/pubmed/21537744

Delayed treatment with vitamin C and N-acetyl-L cysteine protects Schwann cells without compromising the anti-myeloma activity of bortezomib

Nakano A, Abe M, Oda A, Amou H, Hiasa M, Nakamura S, Miki H, Harada T, Fujii
S, Kagawa K, Takeuchi K, Watanabe T, Ozaki S, Matsumoto T. Delayed treatment
with vitamin C and N-acetyl-L: -cysteine protects Schwann cells without
compromising the anti-myeloma activity of bortezomib. Int J Hematol. 2011
Apr 28.

Assessing the survival of mrc-5 and a549 cell lines upon exposure to ascorbic Acid and sodium ascorbate - biomed 2011

Farah IO, Lewis VL, Ayensu WK, Mahmud O. Assessing the survival of mrc-5 and
a549 cell lines upon exposure to ascorbic Acid and sodium ascorbate - biomed
2011. Biomed Sci Instrum. 2011;47:201-6.

Does prophylactic therapy with antioxidant vitamins have an effect on atrial fibrillation following cardiac surgery?

Rasoli S, Kourliouros A, Harling L, Athanasiou T. Does prophylactic therapy
with antioxidant vitamins have an effect on atrial fibrillation following
cardiac surgery? Interact Cardiovasc Thorac Surg. 2011 Apr 26. [Epub ahead
of print] PubMed PMID: 21525032

Two of the studies show that prophylactic treatment with adjuvant vitamin C
and beta-blockers is more effective than beta-blocker therapy alone. The
quality of these studies was assessed using a Jadad scor ing system, which
identified four of the studies to be of low and one to be of high
methodological quality.

Vitamin C status is related to proinflammatory responses and impaired vascular endothelial function in healthy, college-aged lean and obese men

Mah E, Matos MD, Kawiecki D, Ballard K, Guo Y, Volek JS, Bruno RS. Vitamin C
status is related to proinflammatory responses and impaired vascular
endothelial function in healthy, college-aged lean and obese men. J Am Diet
Assoc. 2011 May;111(5):737-43. PubMed PMID: 21515122

These data suggest that low vitamin C status is associated with
proinflammatory responses and impaired vascula r function in lean and obese
men.


http://www.ncbi.nlm.nih.gov/pubmed/21515122

Protective effects of vitamin C against haematological and biochemical toxicity induced by deltamethrin in male Wistar rats

Mongi S, Mahfoud M, Amel B, Kamel J, Abdelfattah EF. Protective effects of
vitamin C against haematological and biochemical toxicity induced by
deltamethrin in male Wistar rats. Ecotoxicol Environ Saf. 2011 Apr 21. [Epub
ahead of print] PubMed PMID: 21514672

Co-administration of vitamin C to the group III restored all the parameters
cited above to near-normal values.

Dietary Intakes of Antioxidant Vitamins and Mortality From Cardiovascular Disease - The JACC Study

Kubota Y, Iso H, Date C, Kikuchi S, Watanabe Y, Wada Y, Inaba Y, Tamakoshi
A; the JACC Study Group. Dietary Intakes of Antioxidant Vitamins and
Mortality From Cardiovascular Disease: The Japan Collaborative Cohort Study
(JACC) Study. Stroke. 2011 Apr 21.

Transmission of hepatitis C virus to recipients of parenteral vitamin therapy in a primary care facility.

Smedley EJ, Stelzer-Braid S, Ressler KA, Melling P, Bowden S, McCaw R, White PA, Vickers CR, Rawlinson WD, Ferson MJ. Transmission of hepatitis C virus to recipients of parenteral vitamin therapy in a primary care facility. J Clin Virol. 2011 Apr 18. PubMed PMID: 21507711.

Access to Parenteral Thiamine

Biological Therapies supplies a range of registered injections containing parenteral thiamine.
See the TGA website:  http://www.tga.gov.au/safety/alerts-medicine-ivthiamine-100728.htm

Pub Med Highlights